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Codex Berinensis, a Florentine copy of an ancient Roman medical treatise , is undated but contains clues to when it was produced. Its first 80 pages are by a single copyist, but the remaining 20 pages are by three different copyists, which indicates some significant disruption. Since a letter in handwriting identified as that of the fourth copyist mentions a plague that killed many people in Florence in 1148, Codex Berinensis was probably produced in that year. : Critical Reasoning (CR)